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Observe Carefully (3)pentobarbital will decrease the extent or impact of diazepam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Powerful or moderate CYP3A4 inducers may perhaps raise price of diazepam elimination; as a result, efficacy of diazepam might be lessened.pentobarbital will lower the extent or e